On-Line Solid Phase Extraction Liquid Chromatography-Mass Spectrometry Method for Multiplexed Proteins Quantitation in an Ecotoxicology Test Specie: Gammarus fossarum

On-line solid-phase extraction for liquid chromatography-mass spectrometry analysis of pesticides.

Public concern about pesticides in food and water has increased dramatically in the last two decades. In order to guarantee consumers' health and safety, analytical methods that could provide fast and reliable answers without compromising accuracy and precision are required. Sample treatment is probably the most tedious and time-consuming step in many analytical procedures and, despite the sign...

ON-LINE SOLID-PHASE EXTRACTION AND LIQUID CHROMATOGRAPHY/PARTICLE BEAM-MASS SPECTROMETRY FOR DEGRADATION STUDIES OF SOME POLAR PESTICIDES IN WATER

An on-line automated method for photodegradation studies of isoproturon, diuron, atrazine, fenitrothion, and metoxuron by means of liquid chromatography/mass spectrometry (LC/MS) with particle beam (PB) interface is described. Surface water samples were first spiked with 50 µg/l of each pesticide and then exposed to the radiation of the medium-pressure mercury lamp. Next, in regular intervals o...

Quantification of sirolimus by liquid chromatography-tandem mass spectrometry using on-line solid-phase extraction.

Quantification of the new immunosuppressant sirolimus (syn. rapamycin; Rapamune) in whole blood by chromatography is essential for its clinical use since no immunoassay is available although monitoring is mandatory. Here we report on a rapid and convenient liquid chromatography (LC-tandem mass spectrometry method and describe our practical experience with its routine use. Whole blood samples we...

An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry.

BACKGROUND Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim. METHODS Following protein precipitation, on-line solid phase extraction was performed for sam...

Extraction and Detection of Pentobarbital in Soil by Solid Phase Extraction and Liquid Chromatography / Mass Spectrometry